Download Chemical Sensitivity and Sick-Building Syndrome by Yukio Yanagisawa, Hiroshi Yoshino, Satoshi Ishikawa, Mikio PDF

By Yukio Yanagisawa, Hiroshi Yoshino, Satoshi Ishikawa, Mikio Miyata

Written by way of multidisciplinary specialists in drugs, chemistry, and structure, this e-book examines chemical sensitivity (CS). In 15 chapters suited to 15 lectures, it discusses not just the clinical clarification, but additionally the environmental components of this allergy, akin to chemistry and architectural features. The publication overviews pollution-induced ailments equivalent to Minamata ailment. It additionally issues out the similarity of recent allergic reaction syndromes to old pollutants ailments from the viewpoints of not just normal clinical elements, but in addition social figuring out of the disease.

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Sample text

Polymorphisms of paraoxionase (PON1) and their significance in clinical toxicology of organophosphates. J Toxicol Clin Toxicol 41:37–45. Sakabe K, Miyata M, Ishikawa S. 2003. Thinking on chemical sensitivity. Neuroophthalmol Jpn 20:350–354. 14. De Luca C, Scordo MG, Cesareo E et al. 2010. Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes. Toxicol Appl Pharmacol 248:285–292. 15. Tran MT, Arendt-Nielsen L, Kupers R et al.

The limbic system influences the endocrine system, including the hypothalamus–pituitary–adrenal axis, which is the center of the stress reaction. Many diseases can affect this system, such as chemical sensitivity, fibromyalgia, chronic fatigue syndrome, organic phosphorus intoxication, Gulf War syndrome, allergy, and organic chlorine intoxication. Environmental pollution has also been considered to contribute to anaphylactic enteritis syndrome and developmental disorder. To date, the mechanism of CS has been discussed mainly in the context of effects of chemical substances on the limbic system and their involvement in the kindling phenomenon [15].

In research on the action of a chemical (xenobiotic) substance in the body involving disruption of endocrine function, the action of bisphenol A did not follow the pattern of a monotonic dose–response curve seen in classic poisoning. A very small quantity of a chemical substance shows a completely different, polytonic, dose–response curve [4]. It has been commonly recognized that the symptoms of CS develop from chemical substance exposure in many cases, and a nervous system sensitivity reaction occurs.

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