By C. Ratledge, J. W. Dale
Tuberculosis maintains to kills extra humans than the other unmarried infective agent. The resurgence of the affliction in lots of nations has produced a heightened wisdom of the possibility posed by way of mycobacterial infections. whilst, there was an explosion of information of the basic houses of mycobacteria, such a lot significantly the decision of the entire genome series of Mycobacterium tuberculosis.
This ebook offers an up to date account of those advancements within the molecular biology and immunology of mycobacteria, coupled with allied advances of a extra utilized nature, comparable to using molecular concepts for prognosis and epidemiological investigations. With chapters contributed from a world workforce of specialists, it's going to not just be an important reference textual content for the increasing mycobacterial examine neighborhood, but additionally will discover a sought after position at the cabinets of clinicians, infectious illness and public healthiness experts, diagnostic laboratories, postgraduate scholars and certainly a person enthusiastic about the administration and research of outbreaks of tuberculosis.
- Comprehensively covers fresh advances within the molecular biology of the mycobacteria.
- First ebook to be released in this topic because the publishing of the total genome for the tubercle bacillus (M. tuberculosis).
- Coincides with a world resurgence of tuberculosis.
Content:
Chapter 1 Recombination (pages 1–16): Graham R. Stewart and Johnjoe McFadden
Chapter 2 cellular Genetic components and Plasmids: instruments for Genetic reports (pages 17–37): Christophe Guilhot, Mary Jackson and Brigitte Gicquel
Chapter three Mycobacteriophages (pages 38–58): Graham F. Hatfull
Chapter four Gene Expression and law (pages 59–92): Juliano Timm, Manuel Gomez and Issar Smith
Chapter five Genomics of Mycobacterium Tuberculosis and Mycobacterium Leprae (pages 93–109): Stephen V. Gordon, Karin Eiglmeier, Roland Brosch, Thierry Garnier, Nadine Honore, Bart G. Barrell and Stewart T. Cole
Chapter 6 Molecular Epidemiology: Human Tuberculosis (pages 110–122): Paul van Helden
Chapter 7 Molecular Epidemiology: Mycobacterium Bovis (pages 123–135): Desmond M. Collins
Chapter eight Molecular Epidemiology: different Mycobacteria (pages 136–160): Joseph O. Falkinham
Chapter nine Molecular Diagnostics (pages 161–179): Kathleen D. Eisenach
Chapter 10 Immunodiagnosis of Mycobacterial an infection (pages 180–197): Graham H. Bothamley, David Catty, Richard Clifton?Hadley, Frank Griffin, Glyn Hewinson and John Pollock
Chapter eleven Mycobacterial progress and Dormancy (pages 198–219): M. Joseph Colston and Robert A. Cox
Chapter 12 cellphone Wall: actual constitution and Permeability (pages 220–239): Jun Liu, Clifton E. Barry and Hiroshi Nikaido
Chapter thirteen The Cell?Wall center of Mycobacterium: constitution, Biogenesis and Genetics (pages 240–259): Alain R. Baulard, Gurdyal S. Besra and Patrick J. Brennan
Chapter 14 Iron Metabolism (pages 260–286): Colin Ratledge
Chapter 15 Antibiotics and Antibiotic Resistance in Mycobacteria (pages 287–306): Vera Webb and Julian Davies
Chapter sixteen Immunotherapy for Mycobacterial illnesses (pages 307–334): John L. Stanford and Graham A. W. Rook
Chapter 17 Vaccines (pages 335–355): Douglas B. Lowrie
Chapter 18 Mycobacterial Antigens (pages 356–370): Jelle Thole, Riny Janssen and Douglas Young
Chapter 19 Mycobacterium and the Seduction of the Macrophage (pages 371–388): David G. Russell
Chapter 20 Cytokines in Immunity to Tuberculosis (pages 389–397): Andrea M. Cooper and Ian M. Orme