Download Cancer and Zebrafish: Mechanisms, Techniques, and Models by David M. Langenau PDF

By David M. Langenau

This quantity specializes in defining the original attributes of utilizing the zebrafish melanoma version for locating very important pathways and strength drug pursuits for the remedy of human cancers. utilizing the zebrafish version, the quantity explores oncogene and tumor suppressor discovery, chemical genetic ways, genomics, epigenetics, melanoma imaging, and telephone transplantation. Contributed chapters come from the main famous laboratories operating during this box, which supplies a different standpoint on zebrafish types from a large spectrum of the study neighborhood. moreover, the booklet bargains a close research of the most up-tp-date learn within the sector for particular zebrafish melanoma versions, together with T mobilephone leukemia, rhabdomyosarcoma, liver and pancreatic melanoma, cancer, neuroblastoma, germ mobilephone tumors, and malignant peripheral sheath tumors. A bankruptcy can be devoted to the advance and usage of different piscine types of melanoma. The compilation of chapters within the quantity culminates right into a accomplished and definitive textual content on zebrafish and melanoma, offering a miles wanted source at the strong attributes of the zebrafish version system.

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Additional resources for Cancer and Zebrafish: Mechanisms, Techniques, and Models

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Besides conditional tumor induction, the Cre/lox system also proved its value for detailed lineage tracing [64, 65], which is especially interesting for studies on tumor clones. The so called zebrabow line is derived from the mouse Brainbow model [66, 67] and is based on a construct that contains a promoter, the three red, blue and yellow fluorescent proteins RFP, CFP and YFP, respectively and pairs of lox2272 and loxP sites spanning the first or the first two fluorescent proteins, respectively [68].

Proc Natl Acad Sci U S A 104:1570–1575 86. Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J, Hendrix MJ (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925–932 87. Liu S, Leach SD (2011) Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system. Methods Cell Biol 105:367–381 The Toolbox for Conditional Zebrafish Cancer Models Marie Mayrhofer and Marina Mione Abstract Here we describe the conditional zebrafish cancer toolbox, which allows for fine control of the expression of oncogenes or downregulation of tumor suppressors at the spatial and temporal level.

Mione The Gal4/UAS system can also be utilized for gene interaction studies. In a crossing intensive approach the pancreas cancer model has been tested in mutant background lines for the ribosomal proteins rpl36-/-, rpl23a-/- or rpl36-/-/rpl23a-/- which showed that rpl36 but not rpl23a functions as haploinsufficient tumor suppressor [46]. By far easier is the co-expression of different transgenes. In an activator line driving Gal4 expression under the cytokeratin promoter krt4, Ju et al. investigated the oncogenic effect of UAS controlled mutant sonic hedgehog (SHH) and mutant AKT1 (myrhAkt1) [8].

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