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By Philip M. Parker
In March 2001, the nationwide Institutes of well-being issued the next caution: "The variety of sites delivering health-related assets grows each day. Many websites offer necessary details, whereas others can have info that's unreliable or misleading." moreover, as a result fast elevate in Internet-based info, many hours could be wasted looking out, deciding upon, and printing. on account that in basic terms the smallest fraction of data facing breast melanoma is listed in se's, reminiscent of www.google.com or others, a non-systematic method of net study should be not just time eating, but additionally incomplete. This booklet used to be created for doctors, scholars, and contributors of most of the people who are looking to behavior scientific learn utilizing the main complicated instruments to be had and spending the smallest amount of time doing so.
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Extra info for Breast Cancer - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers
PubMed citation Studies 25 • Genetics of Prostate Cancer (National Cancer Institute) • Gottlieb B, Beitel LK, Wu J, Elhaji YA, Trifiro M. Nuclear receptors and disease: androgen receptor. Essays Biochem. 2004;40:121-36. Review. PubMed citation • Gottlieb B, Beitel LK, Wu JH, Trifiro M. The androgen receptor gene mutations database (ARDB): 2004 update. Hum Mutat. 2004 Jun;23(6):527-33. Erratum in: Hum Mutat. 2004 Jul;24(1):102. PubMed citation • Gottlieb B, Pinsky L, Beitel LK, Trifiro M. Androgen insensitivity.
1 respectively. These regions contain several genes that are highly over expressed. Therefore, the broad aim of this proposal is to examine the prognostic and predictive significance of the 8p11-p12 amplicon in human breast cancer, and to identify genes therein that may be good targets for the development of novel therapeutics. The specific aims of this project are: 1) To complete the fine mapping of the 8p11-p12 amplicon in the SUM-44, SUM-52, and SUM-225 cell lines by Southern blotting using probes for genes known to map to the region of gene amplification in each line, 2) To examine the expression levels of the amplified genes in each cell line by northern blot and RT-PCR, 3) To determine the predictive and/or prognostic significance of amplification of distinct regions of the 8p12-8q11 amplicon, and of specific candidate breast cancer genes, in breast cancer specimens using tissue micro arrays, 4) To test the mechanistic significance of genes found to be amplified and over expressed in the three breast cancer cell lines by transduction of candidate genes into immortalized human mammary epithelial cells, and by antisense techniques to down-regulate over expressed genes in breast cancer cells.
J Mol Med. 2004 May;82(5):298307. Epub 2004 Feb 27. Review. PubMed citation • Lee HJ, Chang C. Recent advances in androgen receptor action. Cell Mol Life Sci. 2003 Aug; 60(8): 1613-22. Review. PubMed citation • Levy-Nissenbaum E, Bar-Natan M, Frydman M, Pras E. Confirmation of the association between male pattern baldness and the androgen receptor gene. Eur J Dermatol. 2005 Sep-Oct;15(5):339-40. PubMed citation • Merry DE. Molecular pathogenesis of spinal and bulbar muscular atrophy. Brain Res Bull.