Download Platelet Proteomics: Principles, Analysis, and Applications by Ángel García-Alonso, Yotis Senis PDF

By Ángel García-Alonso, Yotis Senis

The aim of the e-book is to introduce platelets, and their practical function in thrombotic and heart problems, justifying the relevance of platelet proteomics study. concentration then shifts to the new advancements on mass spectrometry (MS)-based proteomics.  This bankruptcy indicates capability purposes for platelet proteomics now not but carried out.  It comprises examples of post-translational alterations (PTMs) research in platelets.

The moment a part of the booklet makes a speciality of the most study performed thus far on platelet proteomics. This comprises basic proteome mapping through non-gel established separation equipment (MudPit), research of the overall platelet proteome and signaling cascades by means of gel-based separation tools (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). eventually, the final part hyperlinks the platelet transcriptome and alertness to disease.  This part is extremely correct and comprises chapters on proteomics, transcriptomics, useful genomics, platforms biology, and their purposes to platelet-related diseases.

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Platelet Proteomics: Principles, Analysis, and Applications

The aim of the ebook is to introduce platelets, and their practical position in thrombotic and heart problems, justifying the relevance of platelet proteomics examine. concentration then shifts to the hot advancements on mass spectrometry (MS)-based proteomics.  This bankruptcy indicates strength functions for platelet proteomics no longer but conducted.

Extra info for Platelet Proteomics: Principles, Analysis, and Applications

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Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets, Proteomics 9(18):4340–4354 (2009). 117. Hopkins AL, Groom CR, Target analysis: a priori assessment of druggability, Ernst Schering Res. Found. Workshop 2003(42):11–17 (2003). 118. , The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis, Blood 113(20):4942–4954 (2009). 119. Garc´ıa BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF, The platelet microparticle proteome, J.

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