Download Platelet Proteomics: Principles, Analysis, and Applications by Ángel García-Alonso, Yotis Senis PDF
By Ángel García-Alonso, Yotis Senis
The aim of the e-book is to introduce platelets, and their practical function in thrombotic and heart problems, justifying the relevance of platelet proteomics study. concentration then shifts to the new advancements on mass spectrometry (MS)-based proteomics. This bankruptcy indicates capability purposes for platelet proteomics now not but carried out. It comprises examples of post-translational alterations (PTMs) research in platelets.
The moment a part of the booklet makes a speciality of the most study performed thus far on platelet proteomics. This comprises basic proteome mapping through non-gel established separation equipment (MudPit), research of the overall platelet proteome and signaling cascades by means of gel-based separation tools (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). eventually, the final part hyperlinks the platelet transcriptome and alertness to disease. This part is extremely correct and comprises chapters on proteomics, transcriptomics, useful genomics, platforms biology, and their purposes to platelet-related diseases.
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Extra info for Platelet Proteomics: Principles, Analysis, and Applications
Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets, Proteomics 9(18):4340–4354 (2009). 117. Hopkins AL, Groom CR, Target analysis: a priori assessment of druggability, Ernst Schering Res. Found. Workshop 2003(42):11–17 (2003). 118. , The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis, Blood 113(20):4942–4954 (2009). 119. Garc´ıa BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF, The platelet microparticle proteome, J.
Johnson SA, Hunter T, Kinomics, Nat. Meth. 2(1):17–25 (2005). 125. Cohen P, The regulation of protein function by multisite phosphorylation—a 25 year update, Trends Biochem. Sci . 25:596–601 (2000). 126. Sefton BM and Shenolikar S. 2001. Overview of Protein Phosphorylation. Current Protocols in Protein Science. 5. wiley. d02t02. 127. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S, The protein kinase complement of the human genome, Science 298(5600):1912–1934 (2002). 128. Gafken PR, An overview of the qualitative analysis of phosphoproteins by mass spectrometry, Meth.
Chem. 277(15):12874–12878 (2002). 40. Kroner C, Eybrechts K, Akkerman JW, Dual regulation of platelet protein kinase B, J. Biol. Chem. 275(36):27790–27798 (2000). 41. Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF, Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2, J. Clin. Invest . 113(3):441–450 (2004). 42. Morello F, Perino A, Hirsch E, Phosphoinositide 3-kinase signaling in the vascular system, Cardiovasc. Res. 82(2):261–271 (2009). 43.