Download Notch from Neurodevelopment to Neurodegeneration: Keeping by R. B. Rawson (auth.), Yves Christen Ph. D., Alain Israël PDF

By R. B. Rawson (auth.), Yves Christen Ph. D., Alain Israël Dr., Ph. D., Bart De Strooper Ph. D., Frédéric Checler Ph. D. (eds.)

Can molecular mechanisms focused on neural improvement aid us to appreciate, hinder and maybe opposite the process mind ageing and neurodegenerative problems? mind improvement and serve as require complicated mobile and molecular methods managed through a few varied signaling mechanisms. One such signaling mechanism, the Notch pathway, has been well-known as an incredible participant within the law of cellfate judgements in the course of early neural improvement. even though, the motion of this evolutionary conserved and widespread cell-cell interplay mechanism isn't constrained to the constructing frightened method. moreover, contemporary stories have proven that elucidating the mechanism of Notch signaling and its function within the mind is critical for our realizing of neurological problems resembling Alzheimer's sickness and cerebral arteriopathy CADASIL.

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Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate

Can molecular mechanisms excited by neural improvement support us to appreciate, hinder and maybe opposite the process mind getting old and neurodegenerative problems? mind improvement and serve as require complicated mobile and molecular methods managed via a couple of diversified signaling mechanisms.

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Ma Q, Kintner C, Anderson DJ (1996) Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87:43-52. Ma Q, Chen Z, del Barco Barrantes I, de la Pompa JL, Anderson DJ (1998) neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20:469-482. Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS (2000) Requirement for presenilin 1 in facilitating Jagged 2-mediated endoproteolysis and signaling of Notch 1.

Berechid BE, Thinakaran G, Wong PC, Sisodia SS, Nye JS (1999) Lack of requirement for presenilinl in Notchl signaling. Curr Bioi 9:1493-1496. Berezovska 0, Xia, MQ, Hyman BT (1998) Notch is expressed in adult brain, is coexpressed with presenilin-l, and is altered in Alzheimer disease. J Neuropathol Exp NeuroI57:738-745. Berezovska 0, Frost M, McAllen P, Knowles R, Koo E, Kang D, Shen 1, Lu FM, Lux SE, Tonegawa S, Hyman BT (1999a) The Alzheimer-related gene presenilin 1 facilitates Notch 1 in primary mammalian neurons.

1994; Tomita et al. 1996; Ohtsuka et al. 1999; Ohnuma et al. 1999; Bae et al. 2000; Furukawa et al. 2000; Hojo et al. 2000; Maynard et al. 2000; Morrison et al. 2000; Wakamatsu et al. 2000). Notch signaling is capable of triggering the expression of glial cell missing (Udolph et al. 2001), tramtrack (Guo et al. 1996) and erbB2 (Chen et al. 1997), all of which are important for the differentiation into astroglial lineage. This "gliogenic" effect appears to be strong enough that mere transient Notch receptor activation causes a rapid and irreversible loss of neurogenic capacity in the neural stem cells (NSCs) while promoting glial differentiation, even in the presence of neurogenic factors (Morrison et al.

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