Download Extracellular Matrix and The Liver: Approach to Gene Therapy by Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. PDF

By Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. Friedman

Extracellular Matrix of the Liver addresses the fundamental technology of the extracellular matrix and discussesnew concepts for the therapy of cirrhosis of the liver, with a first-rate concentrate on attainable gene therapyapproaches.The chapters are divided into six sections as follows:* easy technology of Extracellular Matrix* Cells liable for Extracellular Matrix construction* Activation Mechanism of Hepatic Cells and sign Transduction* simple technology for Extracellular Matrix Metabolism together with Enzymes and their Inhibitors* Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New recommendations for the remedy of Liver Cirrhosis Key positive aspects* Discusses the potential of gene remedy for liver cirrhosis* contains details on new features of hepatic stellate cells* Written through most sensible specialists in easy technology and scientific hepatology

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1988). Formation of extracellular matrix in normal rat liver: Lipocytes as a major source of proteoglycan. Gastroenterology 95, 441-447. Bissell, D. , Friedman, S. , Maher, J . , and Roll, F. J. (1990). Connective tissue biology and hepatic fibrosis: Report of a conference. Hepatology 11, 488-498. Burgeson, R. E. (1988). New collagens, new concepts. Annu. Rev. Cell. Biol. 4, 551-577. , Durkin, M. , and Chung, A. E. (1983). Synthesis of laminin and entactin by F9 cells induced with retinoic acid and dibutyryl cyclic AMP.

However, there is a threonine residue at position 6 of this domain that could be phosphorylated. , 1998). Immunolabeling of the epidermis revealed that type XI11 collagen was detected both at cell-cell contact sites and at the dermal-epidermal junction. , 1999). , 1999). , 1998). Further, type XVII collagen seems to be a key component of hemidesmosomes. 1. New Insights into the Extracellular Matrix 9 7. Other Collagens Type VI collagen molecules assemble into disulfide-bonded polymers that form beaded microfibrils.

Struc. Bid. 1, 789-794. Shimell. M. , Ferguson, E. , Childs, S. , and O’Connor, M. B. (1991). The Drosophila dorsalventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell 67, 469-48 1. , Goldfarb, M. , Glass, D. , and Yancopoulos, G. D. (1997). An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol. Cell 1, 25-34. 22 I. , Lyons, G. , and Greenspan, D. S. (1994). Bone morphogenetic protein-I and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.

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