Download Encyclopedia of Immunology Research by Meredith E. Daniels PDF

By Meredith E. Daniels

Publication via

Show description

Read or Download Encyclopedia of Immunology Research PDF

Best medical books

Medical Ethics and Medical Law: A Symbiotic Relationship

Scientific legislation and ethics are usually stated in conjunction, and seem jointly in lots of textbooks. yet do they mix to shape a cohesive unit, and do they profit one another? it can be argued that they don't, yet really undergo a symbiotic courting, clashing instead of cooperating. clinical Ethics and scientific legislations examines this dating, and the way the legislation sees scientific ethics.

The Growth of Medical Knowledge

The expansion of data and its results at the perform of medication were problems with philosophical and moral curiosity for a number of many years and should stay so for a few years to come back. the description of the current quantity was once conceived approximately 3 years in the past. In 1987, a convention in this topic used to be held in Maastricht, the Netherlands, at the celebration of the founding of the eu Society for Philosophy of medication and well-being Care (ESPMH).

Medical gases : production, applications and safety

Protecting the whole spectrum of clinical gases, this prepared reference bargains a finished evaluate of creation, scientific gasoline apparatus, clinical fuel verification, and clinical fuel defense criteria. With a transparent concentration all through on protection, the textual content recommends environmentally dependable production practices in the course of each one step of the method: manufacture, garage, shipping, distribution, and in purposes.

Additional info for Encyclopedia of Immunology Research

Sample text

The combination of VACCIMEL and GM-CSF had low toxicity. Delayed-type hypersensitivity increased after vaccination and it was highest in the group with the highest GM-CSF dose (Barrio 2006). In a phase I clinical trial, eleven end-stage melanoma patients were vaccinated intradermally with 3 peptides: MART-1, tyrosinase, and gp100, mixed with tetanus toxoid and GM-CSF. The peptide vaccine was well tolerated at all tested doses, and led to grade 1-2 toxicity only. Although all patients did show a rise in anti-tetanus IgG titers, in only 3 patients peptide-specific CD8 T cells were induced.

Furthermore, carbohydrate Adjuvants in Cancer Vaccinations 7 antigens are typically much less immunogenic than proteins and generally lack any T cell activating epitopes. Successful cancer vaccines have to activate both the cellular and humoral arm of the innate and adaptive immune systems (Belardelli 2002). Accumulating data indicate that induction of CD8+ cytotoxic T cells (CTLs) and a Th1-biased CD4+ T cell response are crucial for an efficient anti-tumor response (Gilboa 2004). Additionally, antibodies may be essential in controlling residual disseminated tumor cells in the blood or tissues (Livingston 1994, MacLean 1996, Zhang H 1998).

Whereas alum appeared to act mainly on macrophages and monocytes, MF59 was shown to additionally target granulocytes. Accordingly, monocytes and granulocytes migrate toward MF59conditioned culture supernatants. In monocytes, both adjuvants lead to increased endocytosis, enhanced surface expression of MHC class II and CD86, and down-regulation of the monocyte marker CD14, which are all phenotypic changes consistent with a differentiation toward Dendritic cells (DCs). In addition, MF59 was found to induce further up-regulation of the maturation marker CD83 and the lymph node-homing receptor CCR7 on differentiating monocytes.

Download PDF sample

Rated 4.21 of 5 – based on 27 votes