Download Encyclopedia of Controlled Drug Delivery by Edith Mathiowitz PDF
By Edith Mathiowitz
Covers all facets of managed drug supply, together with human, agricultural and animal functions. The 70 entries, written by way of a world staff of popular specialists, deals A-to-Z assurance of managed drug supply platforms for researchers within the pharmaceutical and biotechnology industries, agriculture businesses, clinical machine businesses, medical study firms and clinical faculties.
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The synthesis ofpoly(1actide-co-phosphate)s starts with the ring opening of lactide with an aliphatic diol (Scheme The poly(lactide-co-phosphate)s have excellent solubility in a broad range of organic solvents including ethyl acetate and acetonitrile, which are poor solvents for PLGA. Changing the initiation diol does not significantly change the physicochemical properties. As expected, P(DAPG-EOP) with a D,L-Iactide block has an even higher solubility in common organic solvents. The in vitro degradation has been studied in phosphatebuffered saline (PBS) at 37°C using microspheres prepared by the solvent evaporation method (40).
IN VIVO DEGRADATION, BIOCOMPATlBILlTY, AND CYTOTOXICITY The biodegradation and biocompatibility of these PPEs have been evaluated in an SPF Sprage-Dawley rat model. m = 5, P(CHDM-HOP) m = 3, P(CHDM-BOP) m = 1, P(CHDM-EOP) Scheme 7. Structures ofCHDM-based PPEs. 54 BIODEGRADABLEPOLYMERS: POLY(PHOSPHOESTER)S r>. o N-CH3 o HOCH2~CH20H + II ~ NMM CI-P-CI I O(CH 2)5CH 3 trans-CHDM HOP P (trans-CHDM-HOP) Scheme 8. Synthesis ofPCCHDM-HOP). 50 40 ~ :; 30 (J) E. ~ ro 2 20 10 0 0 1 4 5 Figure 9. In vitro degradation ofPPEs with different side chains in PBS at 37°C.
DESIGN, SYNTHESIS, AND PHYSICOCHEMICAL PROPERTIES OF PPES PPEs Based on Poly(Ethylene Terephthalate) Poly(ethylene terephthalate) (PET) is one of the most commonly used biomedical polymers, as in vascular graft ap- 48 BIODEGRADABLE POLYMERS: POLY(PHOSPHOESTER)S o BPA-EP 120 ~ "ro Q) (f) 100 o BPA-EOP • BPA-PP A BPA-POP f 80 2 000 Q) o ~ 60 eo 0 § :> 0 0 40 8 0 0 ft o 0 i tt i The composition of poly(terephthalate-co-phosphate) (contents of TC and phosphoester units) as calculated from the nuclear magnetic resonance (NMR) spectrum is consistent with the charging ratio.