Download Drug Interactions in Infectious Diseases (Infectious by Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai PDF

By Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai

Nationwide Institutes of wellbeing and fitness, Bethesda, MD. useful and accomplished, this article bargains a evaluation of strength drug interactions between anti-infectives, a robust scientific emphasis, thoughts for dealing with and fending off drug interactions, evaluate of analysis layout, and tabular fabric. For healthcare pros. DNLM: Anti-Infective Agents--pharma

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Effects of grapefruit juice ingestion—pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men. Eur J Clin Pharmacol 1997;52:139–145. 62. Rashid TJ, Martin U, Clarke H, et al. Factors affecting the absolute bioavailability of nifedipine. Br J Clin Pharmacol 1995;40:51–58. 63. Kupferschmidt HH, Fattinger KE, Ha HR, et al. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol 1998;45: 355–359.

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DRUG INTERACTIONS AFFECTING DRUG METABOLISM The principal site of drug metabolism is the liver. Metabolism generally converts lipophilic compounds into ionized metabolites for renal elimination. Drug metaboliz- Mechanisms of Drug Interactions 19 Table 2 Potential Mechanisms of Drug Interactions Involving Metabolism Phase I (nonsynthetic) Genetic polymorphisms Inhibition of activity Suppression of activity Induction of activity Phase II (synthetic) Genetic polymorphisms Inhibition of activity Induction of activity ing activity can be classified according to nonsynthetic (Phase I) and synthetic (Phase II) reactions.

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