Download Drug Delivery and Development of Anti-HIV Microbicides by José das Neves, Bruno Sarmento PDF

By José das Neves, Bruno Sarmento

The world wide influence of HIV/AIDS is easily famous. This ebook offers for the 1st time a radical and demanding evaluation of present points, contemporary advancements, and traits within the formula and drug supply relating anti-HIV microbicides via top scientists within the box. also, pertinent regulatory features and socioeconomical concerns relating to the topic are mentioned. within the absence of a healing, prophylaxis represents a cornerstone within the conflict opposed to an infection. One promising process contains the use round the time of sexual activity of vaginal/rectal items containing antiviral compounds, termed microbicides. it really is now well-known that categorical improvement of drug dosage types and/or drug supply platforms is an necessary element for the luck of microbicides. varied teams strived during the last decade to optimize the biophysical and technological functionality of conventional dosage kinds (gels, pills, and suppositories) to satisfy the specificities of microbicides use, with no neglecting clients’ personal tastes and affordability concerns. additionally, new formula techniques, reminiscent of vaginal jewelry and movies, nanotechnology-based structures, stimuli-sensitive formulations, distinctive drug supply structures, between others were proposed and are at present present process pre-clinical or maybe scientific checking out.

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D. (2012). Optimising the manufacture, formulation, and dose of antiretroviral drugs for more 31 32 Microbicides for the Prevention of HIV cost-efficient delivery in resource-limited settings: A consensus statement, Lancet Infect. , 12, 550–560. 4. Padian, N. , Shiboski, S. , Glass, S. , and Vittinghoff, E. (1997). Heterosexual transmission of Human Immunodeficiency Virus (HIV) in Northern California: Results from a ten-year study, Am. J. , 146, 350–357. 5. Baggaley, R. , White, R. , and Boily, M.

SiRNAs target HIV genes, the host receptors (CD4, CXCR4, CCR5), as well as host dependency factors required for HIV replication in cells [140–142]. Suppression of HIV infection via RNAi-mediated silencing has been tested in tissue culture models, primary CD4+ T cells and monocyte-derived macrophages (MDMs), vaginal explants and HIVinfected humanized mouse models [143–147]. siRNA treatment silenced gene expression up to 7 days in CD4+ T cells and over three weeks in terminally differentiated MDMs.

Dereuddre-Bosquet et al. [76], engineered stable peptides that mimic the CD4 receptor (miniCD4s), interact with the CD4binding site of viral Env and block mucosal HIV entry in vitro and SHIV transmission in vivo. 3% miniCD4- Antiretroviral Microbicides in Development and Mechanism of Action containing gel administered to six cynomolgus macaques prior to SHIV-162P3 vaginal challenge was shown to provide complete protection in five out of six macaques with no trace of virus in body tissues or antibodies in plasma.

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