Download Crash Course Endocrinology by Richard Murphy, Ronan O'Neill, Daniel Horton-Szar PDF

By Richard Murphy, Ronan O'Neill, Daniel Horton-Szar

Now celebrating over 10 years of good fortune - Crash direction has been particularly devised that will help you get via your assessments very easily. thoroughly revised all through, the recent variation of Crash path is completely adapted to satisfy your wishes through offering every thing you must comprehend in a single position. in actual fact awarded in a attempted and depended on, easy-to-use, layout, every one e-book within the sequence offers whole insurance of the topic in a no-nonsense, trouble-free model. beginning with 'Learning Objectives', every one bankruptcy publications you succinctly throughout the subject, giving complete insurance of the curriculum while warding off pointless and infrequently complicated aspect. every one bankruptcy can be supported through a whole art programme, and contours the ever renowned 'Hints and assistance' packing containers in addition to different helpful aide-memoires. All volumes include an updated self-assessment part which lets you try your wisdom and hone your examination abilities. Authored by way of scholars or junior medical professionals - operating less than shut college supervision - each one quantity has been ready via an individual who has lately been within the examination scenario and so relates heavily on your wishes. So no matter if you want to get out of a repair or target for contrast Crash direction is for you!!

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26 However, it is important to note that the number of glands can vary, as can their location. The function of the parathyroid glands is described in Chapter 8. MICROSTRUCTURE Thyroid gland The thyroid is composed of approximately one million microscopic spherical follicles. The wall of each follicle is made up primarily of epithelial cells, called follicular cells. These cells surround and extend into a colloidfilled space. The follicular cells secrete thyroglobin, a storage form of thyroid hormone, into the colloid.

Tyrosine processing is relatively simple since tyrosine molecules are already within the cell. • Reactive iodine rapidly attaches to the tyrosine molecules within the extracellular thyroglobulin. The reaction is catalysed by TPO, and monoiodotyrosine (MIT or T1) and diiodotyrosine (DIT or T2) are formed. Thyroglobulin synthesis • Tyrosine is converted into the glycoprotein thyroglobulin, which contains approximately 110 tyrosine residues. The processing of iodine involves two stages as plasma iodine concentrations are very low.

Actions Thyroid hormones are responsible in part for the expression of genes in target cells. They are mediated by the same receptors as all steroid hormones (Chapter 1); however, thyroid hormone receptors are found in the nucleus, not the cytoplasm. Fig. 7 shows some of the differences between T3 and T4. T4 is a relatively inactive, stable molecule that can be thought of as a prohormone and provides a reservoir for the more active T3. T3 is found in a higher percentage of active hormone than T4 and has a greater effect on receptors.

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