Download Breast Cancer Immunodiagnosis and Immunotherapy by Grant MacLean, Alexander McEwan, Eleanor Mackie, Peter Fung, PDF
By Grant MacLean, Alexander McEwan, Eleanor Mackie, Peter Fung, Carina Henningsson (auth.), Roberto L. Ceriani (eds.)
The convening of the third overseas Workshop on Monoclonal Antibodies and Breast melanoma had the nature of a self-search workout. After virtually a decade of analysis within the uncomplicated and utilized facets of using serological capability to diagnose and doubtless deal with breast melanoma a number of milestones were reached. between them a transparent realizing of immunopathological use and barriers of monoclonal antibodies opposed to breast epithelium, the total improvement and medical use of immunoassays for circulating breast epithelial antigens, the notable advances within the diagnostic use of monoclonal antibodies to estrogen and progesterone receptor proteins and the 1st communications on proposed immunotherapeutic use of alternative conjugates of anti-breast antibodies. New components of research have constructed in our box, a few that are attaining a whole blossom whereas others are nonetheless dealing with hindrances and from time to time a re-definition in their pursuits and goals. those conferences have acted in a manner as a clearing condominium and feature authorised their attendees to derive predictions that experience assisted in shaping destiny study and fine-tune targets. yet in particular, the re-examination of prior examine at those Workshops and the renewed pleasure dropped at them by means of new details has helped generate a momentum and exuberance that assures for the longer term huge clinical gains.
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Extra resources for Breast Cancer Immunodiagnosis and Immunotherapy
The patterns of DF3 antigen expression in a patient with metastatic breast cancer and ten of her family members suggest that the DF3 antigenic heterogeneity is a result of a genetically determined polymorphism which is expressed in an autosomal, codominant fashion (Figure 2). I a: N 1 2 3 4 9 10 11 S I R Figure 2. Relationship of DF3 electrophoretic mobilities among family members. A. Family pedigree and schematic representaion of DF3 antigen mobilities for each member. B. Immunoblot results obtained for plasma samples from the family members.
He antigen can be easily identified in this G200 fraction by western blotting with either JOB1 or 6052 antibody. When the G200 fraction is passed over an affinity column coupled with either of these monoclonal antibodies the antigen can be purified. his purified antigen, which stains with both Coomasie and Alcyan blue irrlicating it is a glycoprotein, is very positive in our antigen elisa and can be easily seen by western blot analysis. We have injected this antigen into rabbits and obtained antibody which will react with hUIl'a11 breast tLnnor cells.
Sci. USA 80:7328-7332 (1983). 20. P. M. Capone, L. D. Papsidero and T. M. Chu, Relationship between antigen density and immunotherapeutic response elicited by monoclonal antibodies against solid tumors. ~ Natl. Cancer lnst. 72:673-677 (1984). 21. R. L. Ceriani and E. W. Blank, An experimental model for the immunological treatment of breast cancer, in: "Monoclonal Antibodies and Breast Cancer," R. L. , Martinus Nijhoff, Boston, p. 248-268 (1985). 22. R. L. Ceriani, E. W. Blank and J. A. Peterson, Experimental immunotherapy of human breast carcinomas implanted in nude mice with a mixture of monoclonal antibodies against human milk fat globule components.