Download Autoantibodies by Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD PDF
By Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD
Autoimmune illnesses are characterised by way of the incidence of antibodies reacting with self-constituents of the physique. The absolutely up to date 3rd version of Autoantibodies is an in-depth evaluation of the most autoantibodies pointed out in the past, with specific emphasis on those who exhibit a diagnostic or prognostic scientific worth.
The re-creation covers fresh medical advances, diagnostic innovations, and healing applied sciences. every one bankruptcy is targeted on a unmarried kinfolk of autoantibodies. this significant reference includes historic notes, definitions, origins and assets of antigens well-known genetic institutions, mediated pathogenic mechanisms, equipment of detection, in addition to medical application (disease occurrence and organization, diagnostic price, sensitivity and specificity, prognostic value). this is often an incredible reference for an individual interested in the sector of autoimmune illnesses.
- Presents all identified, very important autoantibodies in one resource, concentrating on the antibodies wanted for autoimmune sickness diagnosis
- Includes scientific functions for every autoantibody besides basic information
- Organized via affliction and sickness variety, by way of autoantibody kin, and entirely cross-referenced
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Extra resources for Autoantibodies
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The extent of the I/R injury determines the severity of the insult in the event of myocardial infarction, cerebral vascular accident (CVA), and intestinal ischemia. During an ischemic event, the cell undergoes many alterations in regards to its morphology due to membrane damage and protein and lipid lysis by processes of ion imbalance, protease and kinase activation, and mitochondrial changes, which ultimately denotes the appearance of ischemic antigens. These antigens are recognized by the innate immune system, specifically pathogenic natural IgM clone from B-l, resulting in an acute inflammatory response mediated via the lectin pathway that in the end leads to tissue injury and, if left untreated, tissue necrosis [51–54].
Autoantibodies to tumor-associated antigens: reporters from the immune system. Immunol Rev 2008;222:328–40.  Adamus G. Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. Autoimmun Rev 2009;8:410–4.  Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist 2009;15:21–33.  Lakota K, Zigon P, Mrak-Poljsak K, Rozman B, Shoenfeld Y, Sodin-Semrl S. Antibodies against acute phase proteins and their functions in the pathogenesis of disease: a collective profile of 25 different antibodies.