Download Autoantibodies by Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD PDF

By Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD

Autoimmune illnesses are characterised by way of the incidence of antibodies reacting with self-constituents of the physique. The absolutely up to date 3rd version of Autoantibodies is an in-depth evaluation of the most autoantibodies pointed out in the past, with specific emphasis on those who exhibit a diagnostic or prognostic scientific worth.

The re-creation covers fresh medical advances, diagnostic innovations, and healing applied sciences. every one bankruptcy is targeted on a unmarried kinfolk of autoantibodies. this significant reference includes historic notes, definitions, origins and assets of antigens well-known genetic institutions, mediated pathogenic mechanisms, equipment of detection, in addition to medical application (disease occurrence and organization, diagnostic price, sensitivity and specificity, prognostic value). this is often an incredible reference for an individual interested in the sector of autoimmune illnesses.

  • Presents all identified, very important autoantibodies in one resource, concentrating on the antibodies wanted for autoimmune sickness diagnosis
  • Includes scientific functions for every autoantibody besides basic information
  • Organized via affliction and sickness variety, by way of autoantibody kin, and entirely cross-referenced

Show description

Read Online or Download Autoantibodies PDF

Similar infectious diseases books

Current Topics in Complement II

Aegean meetings is an self sustaining, nonprofit, academic association directed and controlled by way of the clinical group. The board is made from 9 researchers/scientists in a variety of disciplines from Harvard, Brown, collage of Pennsylvania, UCSD, Princeton, Biovista and the basis for Biomedical study Academy of Athens.

Der Experimentator: Immunologie

Lieber EXPERIMENTATOR,seit der Erstauflage im Jahr 2004 ist nun die four. Auflage des Immuno-EXPERIMENTATORS erschienen. Das Werk präsentiert die methodische Vielfalt der Immunologie, indem es die gängigen Methoden auf einfache Weise erklärt und auf Vor- und Nachteile sowie auf kritische Punkte eingeht.

Extra resources for Autoantibodies

Sample text

Arthritis Rheum 2011;63:1086–96. [66] Jiang C, Zhao ML, Waters KM, Diaz M. Activation-induced deaminase contributes to the antibody-­ independent role of B cells in the development of autoimmunity. Autoimmunity 2012;45:440–8. [67] Forger F, Matthias T, Oppermann M, Becker H, Helmke K. Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis. Lupus 2004;13:36–44. [68] Shoenfeld Y, Blank M, bu-Shakra M, Amital H, Barzilai O, Berkun Y, et al.

The extent of the I/R injury determines the severity of the insult in the event of myocardial infarction, cerebral vascular accident (CVA), and intestinal ischemia. During an ischemic event, the cell undergoes many alterations in regards to its morphology due to membrane damage and protein and lipid lysis by processes of ion imbalance, protease and kinase activation, and mitochondrial changes, which ultimately denotes the appearance of ischemic antigens. These antigens are recognized by the innate immune system, specifically pathogenic natural IgM clone from B-l, resulting in an acute inflammatory response mediated via the lectin pathway that in the end leads to tissue injury and, if left untreated, tissue necrosis [51–54].

Autoantibodies to tumor-associated antigens: reporters from the immune system. Immunol Rev 2008;222:328–40. [31] Adamus G. Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic ­retinopathy. Autoimmun Rev 2009;8:410–4. [32] Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist 2009;15:21–33. [33] Lakota K, Zigon P, Mrak-Poljsak K, Rozman B, Shoenfeld Y, Sodin-Semrl S. Antibodies against acute phase proteins and their functions in the pathogenesis of disease: a collective profile of 25 different antibodies.

Download PDF sample

Rated 4.60 of 5 – based on 20 votes