Download Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis PDF

By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between quite a few human pathogenic microorganisms corresponding to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as some of the most very important scientific demanding situations of this century. elevated normal wisdom and worry of those pathogens skill there's a starting to be call for for learn to take on the specter of multidrug resistance. Documenting the most recent study within the box, this booklet discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

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2006), who demonstrated that soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. The authors of this important finding concluded that the study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms. More recently, Wright (2010) showed that environmental microbes are highly drug resistant, that the genes that form the environmental resistome have the potential to be transferred to pathogens and that there is some evidence that some clinically relevant resistance genes originated in environmental microbes.

Journal of Infection and Chemotherapy 13, 87–91. Tegos, G. (2006) Substrates and inhibitors of microbial efflux pumps; redefine the role of plant antimicrobials. In: Rai, M. C. ) Naturally Occurring Bioactive Compounds: a New and Safe Alternative for Control of Pests and Microbial Diseases. Cambridge University Press, Cambridge, UK. Tegos, G. R. (2006) Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps. Antimicrobial Agents and Chemotherapy 50, 196–203.

Guillemont, J. and Andries, K. (2011) The challenge of new drug discovery for tuberculosis. Nature 469, 483–490. L. J. (2000) Caenorhabditis Emerging Discovery Strategies elegans is a model host for Salmonella typhimurium. Current Biology 10, 1543–1545. , Auffray, Y. C. (2009) ace, which encodes an adhesin in Enterococcus faecalis, is regulated by Ers and is involved in virulence. Infection and Immunity 77, 2832–2839. , Ishida, H. and Lomovskaya, O. (2000) Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance.

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