Download Ageing : the paradox of life by Robin Holliday PDF
By Robin Holliday
For hundreds of years humans were wondered via the inevitability of human getting older. for many of the second one 1/2 the 20th century getting older remained a secret, or an unsolved organic challenge. on the finish of the twentieth century a amazing clinical discovery emerged. It was once now not a unmarried discovery within the ordinary experience, since it used to be according to a chain of vital interconnected insights over relatively an extended time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it could actually already be acknowledged, despite the fact that, that the numerous observations and insights that specify getting older are not accredited as validated wisdom for a very long time. the sector remains to be filled with scientists, and non-scientists, who're simply satisfied to head on speculating concerning the 'mystery' of getting older. the purpose of this publication is to dispel lack of knowledge through explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of existence.
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Additional resources for Ageing : the paradox of life
The cell division which produces nuclei with only one copy of each gene, also re-assorts different genes into a multitude of different combinations. Thus, all the progeny in sexual reproduction are genetically different from each other, whereas in asexual reproduction they are all the same, forming a clone. For our purpose, we can just accept the fact that sexual reproduction evolved, and also that it is beneficial because it is so widespread in nature. There is not much doubt that early multicellular organisms reproduced both by sexual reproduction and also by asexual, or vegetative reproduction.
No theory is entirely correct, in that it alone ‘explains’ ageing, but several have a considerable degree of validity. Thus we need to have a more global view of all theories. because only in this way can we explain the multiple and irreversible causes of ageing. Many of the causes of ageing I have outlined take place in nondividing cells. What about cells capable of cell division? In these cases cells that die or are lost, for whatever reason, should be be replaced by new cells. However, it is now well established that many types of dividing cells have in fact limited growth potential.
The important point, however, is that all types of animals find themselves in hostile environments, which produce age-structured populations. For this reason, ageing probably did not evolve once, but several times in different taxonomic groups. One of the most successful of these comprises the vast array of insect species. Many of these species, like the roundworm, have adult bodies with very few, if any, cells capable of division, apart from their germ cells. In general, they have limited powers of regeneration, and their bodies have finite survival times.