Download Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, PDF

By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A complete assessment of the new advancements in DNA fix learn that experience capability for translational functions. The ebook explains intimately a few of the organic mechanisms wherein melanoma cells can sidestep anticancer remedy and boundaries its usefulness in sufferers. additionally they evaluation the influence of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of alternative DNA fix enzymes resembling PARP and DNA-PK. The publication captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many interesting new makes use of of DNA fix inhibitors, both on my own or together with anticancer therapies.​

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J Exp Med 186(6):921–929 14. Lees-Miller SP, Godbout R, Chan DW et al (1995) Absence of p350 subunit of DNA activated protein kinase from a radiosensitive human cell line. Science 267(5201):1183–1185 15. Burma S, Chen BP, Chen DJ (2006) Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) 5(9–10):1042–1048 16. Goodhead DT (1994) Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol 65(1):7–17 17. Ward JF (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.

Jeggo P, Lavin MF (2009) Cellular radiosensitivity: how much better do we understand it? Int J Radiat Biol 85(12):1061–1081 6. O’Driscoll M, Jeggo PA (2006) The role of double-strand break repair—insights from human genetics. Nat Rev Genet 7(1):45–54 7. Begg AC, Stewart FA, Vens C (2011) Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 11(4):239–253 8. Helleday T, Petermann E, Lundin C et al (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8(3):193–204 9.

However, in tumor tissues, the expression of DNA-PK shows intratumor heterogeneity, suggesting difficulty in predicting the radio- or chemo-sensitivity of the tumor as well as when a DNA-PK inhibitor may be beneficial [174]. Strategies that block DNA repair will increase damage in the treated cells and result in increased cell death. Such approaches enhance sensitivity to treatment, although they do not provide selectivity against cancer cells as they increase the radiosensitivity or chemosensitivity of normal cells as well.

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